Screen Browser
| TITLE | AUTHOR | LABORATORY | SPECIES (MODALITY) | MODE | T CELL TYPE | EXPERIMENTAL PERTURBATION | LIBRARY SIZE (GENES) | LIBRARY NAME | REFERENCE |
| TRM METABOLISM | Miguel Reina-Campos | Ananda Goldrath | Mouse (in vivo) | CRISPR KO | Cas9GFP P14 CD8 T cells | LCMV Armstrong | 3,017 | Birçoi_Metabolism | 37648857 |
| TIL METABOLISM | Jun Wei | Hongbo Chi | Mouse (in vivo) | CRISPR KO | Cas9GFP OT-I CD8 T cells | B16F10 (Tumor) | 3,017 | Birçoi_Metabolism | 31827283 |
| TRM MITOCHONDRIA–LYSOSOME | Jana L. Raynor | Hongbo Chi | Mouse (in vivo) | CRISPR KO | Cas9 Ovalbumin (OVA)-specific OT-I CD8 T cells | Listeria Monocytogenes Expressing OVA (LM-OVA) | 1,589 | Mitochondria–Lysosome | 39406246 |
| GENOME WIDE HUMAN T CELL PROLIFERATION | Eric Shifrut | Alexander Marson | Human (in vitro) | CRISPR KO | Primary Human T Cells | TCR Stimulation | 19,114 | sgRNA Library for Targeting Cell Surface and TCR Signaling Genes | 30449619 |
| METABOLIC REGULATORS FOR CD8+ T CELL FATE DECISIONS | Hongling Huang | Hongbo Chi | Mouse (in vivo) | CRISPR KO | Cas9GFP P14 CD8 T cells | LCMV Armstrong | 3,017 | Birçoi_Metabolism | 33636132 |
| OpTICS identifies TF involved in TEFF and TEX cell differentiation | Zeyu Chen | Junwei Shi & E. John Wherry | Mouse (in vivo) | CRISPR KO | Cas9GFP P14 CD8 T cells | LCMV Armstrong | LCMV Clone13 | 136 | Transcription Factor Subset | 33636129 |
| Genome-wide identification of CD8 T cell fitness genes in vivo and in vitro | Hanfei Zhao | Min Peng | Mouse (in vivo) | CRISPR KO | Cas9GFP OT-I CD8 T cells | Transfer (In vivo) or Culture (In vitro) | 19,674 | Brie Genome-Wide sgRNA Library | 34879274 |
| Multiple genome-wide CRISPR screens in primary human T cells | Julia Carnevale | Alexander Marson | Human (in vitro) | CRISPR KO | Primary Human T Cells | Adenosine, Stim, Tregs, Cyclosporine, Tacrolimus, and TGFb | 19,114 | Brunello sgRNA Library | 36002574 |
| Genome-wide CRISPR screens identify genetic regulators of T cell exhaustion | Julia A. Belk | Ansuman T. Satpathy | Mouse (in vivo) | CRISPR KO | CD8+ T Cells | in vitro acute (IL-2 only) and chronic (anti-CD3 and IL-2) stimulation | 18,424 | Teichmann Genome-wide CRISPR Knockout Library (Pooled Library #104861) | 35750052 |
| Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness | Chun-Pu Lin | Daniel S Peeper | Mouse (in vivo) | CRISPR KO | Cas9GFP OT-I CD8 T cells | In Vitro Intense, Acute, Chronic Stimulation | 19,674 | Brie genome-wide sgRNA library | 38490212 |