| TRM Metabolism | Miguel Reina-Campos | Ananda Goldrath | Mouse (in vivo) | CRISPR KO | Cas9GFP P14 CD8 T cells | LCMV Armstrong | 3,017 | Birçoi_Metabolism | 37648857 |
| TIL Metabolism | Jun Wei | Hongbo Chi | Mouse (in vivo) | CRISPR KO | Cas9GFP OT-I CD8 T cells | B16F10 (Tumor) | 3,017 | Birçoi_Metabolism | 31827283 |
| TRM Mitochondria–Lysosome | Jana L. Raynor | Hongbo Chi | Mouse (in vivo) | CRISPR KO | Cas9 Ovalbumin (OVA)-specific OT-I CD8 T cells | Listeria Monocytogenes Expressing OVA (LM-OVA) | 1,589 | Mitochondria–Lysosome | 39406246 |
| Genome Wide Human T cell proliferation | Eric Shifrut | Alexander Marson | Human (in vitro) | CRISPR KO | Primary Human T Cells | TCR Stimulation | 19,114 | Brunello sgRNA Library | 30449619 |
| Metabolic Regulators for CD8+ T Cell Fate Decisions | Hongling Huang | Hongbo Chi | Mouse (in vivo) | CRISPR KO | Cas9GFP P14 CD8 T cells | LCMV Armstrong | 3,017 | Birçoi_Metabolism | 33636132 |
| OpTICS identifies TF involved in TEFF and TEX cell differentiation | Zeyu Chen | Junwei Shi & E. John Wherry | Mouse (in vivo) | CRISPR KO | LCMV Armstrong | LCMV Clone13 | LCMV Armstrong | 136 | Transcription Factor Subset | 33636129 |
| Genome-wide identification of CD8 T cell fitness genes in vivo and in vitro | Hanfei Zhao | Min Peng | Mouse (in vivo) | CRISPR KO | Cas9GFP OT-I CD8 T cells | Transfer (In vivo) or Culture (In vitro) | 19,674 | Brie Genome-Wide sgRNA Library | 34879274 |
| Multiple genome-wide CRISPR screens in primary human T cells | Julia Carnevale | Alexander Marson | Human (in vitro) | CRISPR KO | Primary Human T Cells | Adenosine, Stim, Tregs, Cyclosporine, Tacrolimus, and TGFb | 19,114 | Brunello sgRNA Library | 36002574 |
| Genome-wide CRISPR screens identify genetic regulators of T cell exhaustion | Julia A. Belk | Ansuman T. Satpathy | Mouse (in vivo) | CRISPR KO | CD8+ T Cells | in vitro acute (IL-2 only) and chronic (anti-CD3 and IL-2) stimulation | 18,424 | Teichmann Genome-wide CRISPR Knockout Library (Pooled Library #104861) | 35750052 |
| Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness | Chun-Pu Lin | Daniel S Peeper | Mouse (in vivo) | CRISPR KO | Cas9GFP OT-I CD8 T cells | In Vitro Intense, Acute, Chronic Stimulation | 19,674 | Brie Genome-Wide sgRNA Library | 38490212 |
| CRISPR activation screens decode stimulation responses in primary human T cells | Ralf Schmidt | Alexander Marson | Human (in vitro) | CRISPRa | Primary Human T Cells | In Vitro Stimulation | 18,885 (Set A), 18,843 (Set B) | Calabrese (CRISPRa) sgRNA library | 35113687 |
| CRISPR interference screens decode stimulation responses in primary human T cells | Ralf Schmidt | Alexander Marson | Human (in vitro) | CRISPRi | Primary Human T Cells | In Vitro Stimulation | 18,901 (Set A), 18,899 (Set B) | Dolcetto (CRISPRi) sgRNA library | 35113687 |
| In vivo CRISPR screen identifies metabolic genes regulating CD8+ T cell fitness | Samantha Pretto | Mario Di Matteo & Massimiliano Mazzone | Mouse (in vivo) | CRISPR KO | Cas9GFP OT-I CD8 T cells | KPC_OVA (Tumor) | 2,078 | Metabolic single guide RNA (sgRNA) library | 40065102 |
| CRISPR screening for regulators of FOXP3 | Kelvin Y. Chen | Shimon Sakaguchi | Human (in vitro) | CRISPR KO | Primary Human CD4+ T cells | iTreg induction | 19,114 | Brunello sgRNA Library | 40140585 |